Gold amides as anticancer drugs: synthesis and activity studies.

نویسندگان

  • Sonya Newcombe
  • Mariusz Bobin
  • Amruta Shrikhande
  • Chris Gallop
  • Yannick Pace
  • Helen Yong
  • Rebecca Gates
  • Shuvashri Chaudhuri
  • Mark Roe
  • Eva Hoffmann
  • Eddy M E Viseux
چکیده

Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 11 19  شماره 

صفحات  -

تاریخ انتشار 2013